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阿糖胞苷代谢酶与急性髓系白血病患者临床耐药关系的研究 被引量：3

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作者 万海霞 陈芳源 王海嵘 王婷 钟济华 韩洁英 欧阳仁荣
机构地区 上海第二医科大学附属仁济医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2005年第12期748-750,共3页 Chinese Journal of Hematology
基金 上海市卫生局科研基金资助项目(034080)
关键词 阿糖胞苷 代谢酶 白血病患者 耐药 急性髓系 Ara-C 临床 脱氧胞苷激酶 胞苷脱氨酶 药理作用
分类号 R733.71 [医药卫生—肿瘤]
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参考文献7

  • 1Schroder K, Kirch C, Flasshove M, et al. Constitutive overexpression of the cytidine deaminase gene confers resistance to cytosine arabinoside in vitro. Leukemia, 1996,10:1919-1924.
  • 2Mansson E, Liliemark E, Soderhall S, et al. Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia. Leukemia, 2002,16: 386-392.
  • 3Flasshove M, Strumberg D, Ayscute E, et al. Structural analysis of the deoxycytidine kinase gene in patients with acute myeloid leukemia and resistance to cytosine arabinoside. Leukemia, 1994,8:780-785.
  • 4Colly LP, Peters WG, Richel D, et al. Deoxycytidine kinase and deoxycytidine deaminase values correspond closely to clinical response to cytosine arabinoside remission induction therapy in patients with acute myelogenous leukemia. Semin Oncol, 1987,14: 257-261.
  • 5Jahns-Streubel G, Reuter C, Auf der Landwehr U, et al. Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia. Blood, 1997, 90: 1968-1976.
  • 6Heuvel-Eibrink MM, Wiemer EA, Ewijpers M, et al. Absence of mutations in the deoxycytidine kinase ( DCK ) gene in patients with relapsed and/or refractory acute myeloid leukemia(AML). Leukemia,2001,15: 855-856.
  • 7Stegmann APA, Honders MW, Willemze R, et al. De novo induced mutations in the deoxycytidine kinase (dck) gene in rat leukemic clonal cell lines confer resistance to cytarabine(Ara-C) and 5-aza-2'-deoxycytidine(DAC). Leukemia, 1995,9: 1032-1038.

同被引文献34

  • 1唐跃年,张菀陵.阿糖胞苷及其代谢物在血液中的HPLC测定方法[J].中国药学杂志,1994,29(6):352-354. 被引量：4
  • 2彭娟红,胡建达.胞苷脱氨酶与阿糖胞苷耐药[J].国际输血及血液学杂志,2006,29(3):257-259. 被引量：1
  • 3Rowe JM.What is the best induction regimen for acute myelogenous leukemia[J] ? Leukemia,1998,12(Suppl 1):S16-S19.
  • 4Willemze R,Suciu S,Archimbaud E,et al.A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia:an EORTC Leukemia Cooperative Group phase II study (06893)[J].Leukemia 1997,11(Suppl 1):S24-S27.
  • 5Hu XF,Slater A,Kantharidis P,et al.Altered multidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia[J].Blood,1999,93(12):4086-4095.
  • 6Flasshove M,Strumberg D,Ayscute L,et al.Structural analysis of the deoxycytidine kinase gene in patients with acute myeloid leukemia and resistance to cytosine arabinoside[J].Leukemia,1994,8(5):780-785.
  • 7Gandhi V,Huang P,Chapman AJ,et al.Incorporation of fludarabine and 1-beta-D-arabinofuranosylcytosine 5'-triphosphates by DNA polymerase alpha:affinity,interaction,and consequences[J].Clin Cancer Res,1997,3(8):1347-1355.
  • 8Johansson M,Norda A,Karlsson A.Conserved gene structure and transcription factor sites in the human and mouse deoxycytidine kinase genes[J].FEBS Lett,2000,487(2):209-212.
  • 9Hatzis P,Al-Madhoon AS,Jüllig M,et al.The intracellular localization of deoxycytidine kinase.[J].J Biol Chem,1998,273(46):30239-30243.
  • 10Shi JY,Shi ZZ,Zhang SJ,et al.Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients[J].Pharmacogenetics,2004,14(11):759-768.

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中华血液学杂志
2005年 第12期

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