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Expression of cyclooxyenase-2 protain and its relationship with HIF-1α in HCC

Expression of cyclooxyenase-2 protain and its relationship with HIF-1α in HCC
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摘要 Objective: To investigate the clinical significance of COX-2 (Cyclooxygenase-2) expression in HCC (Primary hepatocellular carcinoma) and clarify whether COX-2 is correlated with hypoxia-inducible factor-1α (HIF-1α) in the development of HCC. Methods: Tumor tissues were obtained from 53 patients with HCC. COX-2 and HIF-1α were determined by immunohistochemistry. All 53 patients were regularly followed up and the data were collected prospectively. Results: Immunostaining showed the expression of COX-2 ( n = 33, 62.3 % ) and HIF-1α ( n = 36, 67.9% ) in most tumor cells. The level of COX-2 was correlated with HIF-1α levels( r = 0.4413, P 〈0.01 ). There were significant correlation between clinicopathological features and higher tumor cytosolic COX-2 level was in the presence of multiple tumors ( P = 0.01), venous invasion ( P = 0.03), advanced tumor stage ( P = 0.01), and well-different tumor grade (P =0.03). High-tumor cytosolic COX-2 level was correlated with patient's worse prognosis (P = 0.0085). Conclusion: Elevated tumor COX-2 level is correlated with elevated HIF-1α levels and invasiveness in HCC, suggesting COX-2 plays an important role in the progression of HCC, and may be an important therapeutic target in HCC. Objective: To investigate the clinical significance of COX-2 (Cyclooxygenase-2) expression in HCC (Primary hepatocellular carcinoma) and clarify whether COX-2 is correlated with hypoxia-inducible factor-1α (HIF-1α) in the development of HCC. Methods: Tumor tissues were obtained from 53 patients with HCC. COX-2 and HIF-1α were determined by immunohistochemistry. All 53 patients were regularly followed up and the data were collected prospectively. Results: Immunostaining showed the expression of COX-2 ( n = 33, 62.3 % ) and HIF-1α ( n = 36, 67.9% ) in most tumor cells. The level of COX-2 was correlated with HIF-1α levels( r = 0.4413, P 〈0.01 ). There were significant correlation between clinicopathological features and higher tumor cytosolic COX-2 level was in the presence of multiple tumors ( P = 0.01), venous invasion ( P = 0.03), advanced tumor stage ( P = 0.01), and well-different tumor grade (P =0.03). High-tumor cytosolic COX-2 level was correlated with patient's worse prognosis (P = 0.0085). Conclusion: Elevated tumor COX-2 level is correlated with elevated HIF-1α levels and invasiveness in HCC, suggesting COX-2 plays an important role in the progression of HCC, and may be an important therapeutic target in HCC.
出处 《Journal of Nanjing Medical University》 2005年第6期299-302,共4页 南京医科大学学报(英文版)
基金 135MedicalEmphansGrantfromGovernmentofJiangsuProvince(13543)
关键词 CYCLOOXYGENASE-2 hypoxia-inducible factor-1α human hepatocellular carcinoma cyclooxygenase-2 hypoxia-inducible factor-1α human hepatocellular carcinoma
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