几种肝脏病变的MRI菲立磁增强表现及诊断价值

Superparamagnetic iron-oxide(SPIO) enhanced MRI manifestations and diagnostic value in several liver diseases

目的:探讨菲立磁(SPIO)增强在肝脏病变中的诊断价值。方法:16例患者行SPIO增强的MRI检查,其中6例为海绵状血管瘤,不均匀脂肪肝4例,肝细胞癌(HCC)3例,局灶结节增生(FNH)、肝腺瘤及肝转移瘤各1例。结果:与MRI平扫相比,肝内海绵状血管瘤在SPIO增强后的T1WI上信号明显增高,而在T2WI上信号强度有轻度下降;在不均匀脂肪肝的病例中,增强后兴趣区与周围肝组织的信号强度对比关系延续了增强前的表现;肝腺瘤和FNH在增强后的T2WI上有明显的信号强度下降:HCC在增强后的T2WI上常无明显信号下降,而在T1WI上却有轻度信号升高;转移瘤在T2WI上无信号下降。结论:SPIO强化MRI对肝内病变的良恶性鉴别诊断有一定的帮助。

Objective：To explore SPIO-enhanced MRI appearances and research its diagnostic value in several kinds of liver diseases. Methods：SPIO-enhanced MRI examination was performed in 16 cases, among 6 cases were cavernous hemangioma, four heterogeneous fatty liver, three HCC, one FNH, one hepatic adenoma and one hepatic metastasis. Results： By comparison with unenhanced MRI, cavernous hemangioma was a higher signal intensity on SPIO-enhanced T1WI, and slightly lower signal intensity on T2WI. In the cases with fatty liver, the signal ratio of the region of interest and surrounding liver was the same as unenhanced MRI examination. There was a evident decrease of signal intensity on SPIO-enhanced T2WI in hepatic adenoma and FNH. However, in HCC cases, there was no marked decrease on T2WI and has slightly increased signal on T1WI. There was no decreased signal on SPIO-enhanced T2WI in the case with metastasis. Conclusion：SPIO-enhanced MRI can asist to diagnose liver disease.