中耳乳突腔富于淋巴浆细胞型脑膜瘤一例并文献复习

Lymphoplasmacyte-rich meningioma in the mastoid:a case report and review of the literature

目的阐明中耳乳突腔的富于淋巴浆细胞型脑膜瘤临床病理学特征。方法运用光镜、免疫组织化学的方法,结合文献资料进行研究探讨。结果瘤细胞为梭形,呈漩涡状排列,部分瘤细胞为上皮样,细胞界限不清、排列成合体样,胞浆丰富,核呈圆形或短梭形,核染色质细,核仁不明显。瘤组织内可见大量的淋巴细胞、浆细胞弥漫性或灶性浸润。免疫组化瘤细胞EMA、VIM阳性,CD34、S-100阴性。结论中耳脑膜瘤无论原发性或继发性都很罕见,有特殊的临床病理学特点,对呈进行性听力下降的患者在诊断时应考虑到。

Objective To elucidate the elinicopathologie features of lymphoplasmacyte-rich meningioma in the mastoid. Methods A case of lymphoplasmacyte-rich meningioma in the mastoid was studied with conventional histopathological and immunohistochemical staining, and a brief literature review is included. Results Microscopically, the tumor was consisted of spindle tumor cells which were arranged in a whorled architecture. Some neoplastic cells were epithelioid that had indistinct cell borders and arranged in syneytial pattern. Tumor cells had a meningothelial appearance with round to oval nuclei, dispersed ehromatin, inconspicuous nueleoli, and eosinophilie cytoplasm, lmmunohistoehemieally, the tumor cells exhibited positive reactivity to EMA and vimentin, but negative reactivity for S-100, CD34 and GFAP. Conclusions Meningioma in the mastoid is a kind of rare meningioma regardless of whether it is primary or secondary. Meningioma has special clinieopathologic features and it should be a differential diagnosis when patients have progressive hearing loss.