巨噬细胞功能在乙肝后肝纤维化免疫发病机制中作用的研究

Study on the Macrophagocyte Function in the Immunal Pathogenesis of Posthepatic Cirrohsis

为研究巨噬细胞功能在乙肝后肝纤维化免疫发病机制中的作用,我们采用ABC-ELISA及放射免疫测定法检测了33例急性乙肝炎,31例乙肝后肝硬化患者血中IFN-γ、PGE_2的水平.结果表明,急性乙肝患者与正常组比较,这两种因子的水平无明显变化;乙肝后肝硬化组显著异常.间接反映了分泌这两种细胞因子的巨噬细胞免疫功能紊乱,提示巨噬细胞的免疫功能在乙肝后肝纤维化发病机制中起着重要的免疫调控作用.

IFN-γ and PGE2 levels of 33 cases with hepatitis B virus (HBV), 31 cases with post hepatitis cirrohsis were analysed by ABC-ELISA and radio immune assay in order to investigate the role of macrophagocyte playing in the immune machmism of post hepatitis cirrhosis. Results show: There is no obvious change in the levels of IFN-γ and PGE2 between two groups of hepatitis B virus (HBV) patient and normal persons but in group of post hepatitis cirrhosis, significant difference was found. It suggestted indirectly that immunofunction of macrophagocyte secreting these two factors is disturbant, and it may play an importante role in the path ogenesis of posthepatitis cirrohsis.