微胶囊技术及其在骨科领域的应用

MICROENCAPSULATION AND ITS APPLIACATION IN ORTHOPAEDICS

目的对微胶囊技术及其在骨科疾病方面的应用进行综述。方法广泛查阅近年相关文献,介绍微胶囊技术的基础知识及其在骨科疾病上的应用。结果较全面地对微胶囊技术的材料、制备方法、性能评价、缓释性能、免疫隔离和可包裹的细胞系进行了回顾,分析了其作为骨科药物和转基因细胞的载体,用于促进骨愈合,基因治疗骨肿瘤、骨感染和骨软骨再生的作用。结论微胶囊可以作为骨科药物和转基因细胞的载体,治疗骨科相关疾病。

Objective To introduce the research update of microencapsulation and its application in orthopedics. Methods Recent articles concerned were extensively reviewed. Results Drugs and cells modified by gene could be encapsulated in different materials and be implanted in vivo avoiding a host immune system rejection. It act as a continuous source of desired medicine for enhancement of bone healing, the treatment of bone tumor and bone infection, and the regeneration of bone and cartilage. Conclusion Microencapsulation can be used as a carrier for drugs and cells modified gene to treat related disease in orthopedics.