肺炎衣原体感染与急性冠脉综合征的相互关系

Relationship between chlamydia pneumoniae infection and acute coronary syndrome

目的探讨肺炎衣原体(CP)感染与急性冠脉综合征(ACS)的相互关系。方法应用固相酶联免疫吸附(ELISA)方法定量检测130例ACS患者、40例非ACS患者和50例健康者血清CP特异性抗体IgG,并同时应用乳胶颗粒凝集试验进行CRP测定。结果CP抗体和CRP阳性率在ACS组明显高于非ACS组和健康组,和健康组比较,P<0.01和P<0.05。结论CP感染可能通过影响动脉粥样硬化斑块的稳定性而增加ACS的危险性。

Objective To investigate the relationship between chlamydia pneumoniae （CP） and acute coronary syndrome （ACS）. Methods CP-specific IgG antibodies were measured by enzyme linked immunosorbent assay （ELISA） and C-reactive protein （CRP） were measured by latex particle agglutination test （LPAT） in 130 cases of ACS and 40 cases of non-ACS and 50 healthy control. Results The rate of seropositive for CP and CRP was significantly higher in the ACS group than the non-ACS group and healthy control group（P〈0.01 and P〈0.05 respectively）. Conclusion CP infection may increase the risk of ACS by influencing stability of atherosclerosis plaque.