血清抵抗素水平与子痫前期的关系

Relationship between serum resistin level and preeclampsia

目的:观察子痫前期患者血清抵抗素水平的变化,探讨抵抗素与子痫前期发生的关系。方法:应用双抗体酶联免疫吸附法(EL ISA),检测正常非妊娠妇女(正常非孕组,28例)、早孕妇女(早孕组,27例)、中孕妇女(中孕组,26例)、晚孕妇女(晚孕组,26例)以及子痫前期患者(子痫前期组,25例)血清抵抗素的浓度。结果:①早孕组(6.660±0.546)μg/L、中孕组(5.058±0.461)μg/L与正常非孕组(5.450±0.418)μg/L血清抵抗素浓度无显著性差异(P>0.05);晚孕组血清抵抗素(8.659±0.698)μg/L显著高于正常组、早孕组以及中孕组(P分别<0.01,0.001和0.001)。②子痫前期组抵抗素水平(5.162±0.484)μg/L低于晚孕组,差异有显著性(P<0.001),但与正常组、早孕组以及中孕组相比差异无显著性(P均>0.05)。结论:血清抵抗素水平降低是子痫前期的重要变化,可能与子痫前期的病情有关。

Objective： To investigate the alteration of serum resistin levels in normal pregnancy and preeclampsia. Methods： Blood samples were take from 28 normal non-pregnant women, 27 women in the 1^st,26 in the 2^nd and 26 in the 3^rd trimester of normal pregnancy and 25 women with preeclampsia. Serum resistin concentration was determined using ELISA method. Results： Serum levels of resistin were not significantly different among non-pregnancy,the 1^st and the 2^nd trimester of pregnancy （P〉0.05 for all）. Serum resistin level was significantly elevated in the 3^rd trimester of pregnancy as compared with non-pregnancy （P〈0.01）,the 1^st（P〈0. 001 ） and the 2^nd trimester of pregnancy （P〈0. 001）. Serum resistin level was significantly lower in preeclampsia than in the 3^rd trimester of normal pregnancy （P〈0. 001）,but was comparable to that of non-pregnancy,the 1^stand the 2^nd trimester of pregnancy （P 〉 0. 05 for all）. Conclusion： The decrease of serum resistin level in the preeclampsia may provide insight into the pathogenesis of the disease.