慢性乙型肝炎和丙型肝炎患者外周血淋巴细胞微核率的研究

ASTUDY OF THE MICRONUCLEUS FREQUENCIES OFPERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITHCHRONIC HEPATITIS B AND C

本文对３３例慢性乙型肝炎和８例慢性丙型肝炎患者外周血淋巴细胞微核率进行了研究。结果表明，慢性乙型肝炎和慢性丙型炎患者微核率比健康者明显增高（Ｐ＜０．０１）。而慢性乙型肝炎与慢性丙型肝炎患者微核率比较没有差异（Ｐ＞０．０５）。提示丙型肝炎病毒和乙型肝炎病毒对肝细胞和淋巴细胞造成的遗传损伤的机理可能是一致的。

Abstract The micronucleus frequencies of peripheral lymphocytes in 33 patients with chron-ic hepatitis B and 8 patients with chronic hepatitis C have been studied.The results showsthat the micronucleus frequency of peripheral lymphocytes of the chronic hepatitis B and Cwas greatly higher than those of the healthy,the difference being very remarkable(P <0.01). However,the microuncleus frequency of chronic hepatitis B than C was not different(P>0.05). These findings suggest that chronic hepatitis B and C virus infection may induceChromosome damage of liver cells and lymphocytes,the mechanism of which may be same.Kev words hepatitis B virus;hepatitis C virus;lymphocyte;micronucleus.