回盲肠间置幽门替代术动物模型的初步探讨

Ileocecal interposition graft as substitute for pylorus in pigs

目的探讨回盲肠间置幽门替代术应用于动物胃肠道重建的可行性。方法将21头成年健康小型猪分为3组:假手术对照组(正常组)、B-I式胃大部切除组和远端胃大部切除带蒂回盲肠间置幽门替代手术组(回盲肠间置组)。术后观察对照动物的生存情况。结果手术后4个月,回盲肠间置组几乎未见呕吐、厌食及食量下降等现象;营养、精神状态及体力与正常组无甚差别;体重与术前无明显变化。而上述现象在B-I式组可见,且精神体力较差,体重较术前降低明显(P<0.05)。结论回盲肠间置替代幽门重建消化道的动物模型可以借鉴。

Objective To evaluate the application of ileocecal interposition （Ⅱ） graft as pylorns in gastrointestinal tract reconstruction. Methods Twenty-one minipigs were randomized into three groups： sham operation group, B-I group and Ⅱ group. The qualities of life （QL） were compared after operation. Results In 4 months after operation, the side effects of the operation including vomit, loss of appetite and other metabolic and nutritional changes nearly disappeared in Ⅱ group and the weight showed no difference with preopemtion, while the side effects were always observed in B-I group and the weight was significantly less than that before operation （ P 〈 0.05）. Conclusion The application of ileocecal interposition graft as pylorns in gastrointestinal tract reconstruction is feasible.