盐酸非索非那定片对变应性鼻炎的前瞻性临床研究

Prospective clinical trial of hydrochloric fexofenadine on allergic rhinitis

目的评价盐酸非索非那定治疗变应性鼻炎的临床疗效及安全性。方法选择60例变应性鼻炎患者,盐酸非索非那定组(实验组)30例,盐酸氯雷他定组(对照组)30例。采用随机、双盲、对照临床研究。结果治疗2周后盐酸非索非那定片组症状总积分变化值与盐酸氯雷他定组无显著性差异(P>0.05),治疗后2周盐酸氯雷他定组的总有效率为70.83%,盐酸非索非那定片组为80.77%(P>0.05)。两组共发生不良反应2例,盐酸氯雷他定组不良反应的总发生率为4%,盐酸非索非那定组为3.7%。结论盐酸非索非那定片治疗变应性鼻炎安全、有效。

Objective To evaluate the curative effect and reliability of hydrochloric levocetirizine on allergic rhinitis. Methods A total of 60 patients suffering form allergic rhinitis who were assigned to receive fexofenadine or loratadine （ n = 30 for each therapy） were studied in multi-center, random, double-blind manner. Results The amelioration of the patients of fexofenadine therapy was similar to that of loratadine therapy 2 weeks later since the treatment began（ P 〉 0.05） while the total efficiency of loratadine therapy was 70.83 %, and that of fexofenadine was 80.77 % （ P 〉 0.05）. Adverse reaction occurred in one patient of each therapy, with the rate of adverse reaction of 4 % for fexofenadine therapy and 3.7 % for loratadine therapy （ P 〉 0.05）. Conclusion Hydrochloric fexofenadine is effective and reliable on allergic rhinitis.