体位性心动过速综合征的年龄和性别差异

Differences between age and gender in postural tachycardia syndrome

目的探讨体位性心动过速综合征(POTS)的年龄和性别差异.方法2001-01～2005-05在中南大学湘雅二医院从316例直立倾斜试验(HUTT)检查中诊断的POTS患者66例,分为成年(＞18岁)和儿童(≤18岁)两组,分析其病程、诊断率、心率变化的年龄和性别差异.结果①病程及发病年龄:POTS病程在成年组1.00～11.33 a(平均5.22±4.33 a),男性略短于女性(3.00±4.24 a vs 5.71±4.44 a,P＞0.05);儿童组0.08～4.00a(平均0.73±1.13 a),男性长于女性(1.21±1.46 avs 0.46±0.81 a,P＜0.05).发病年龄在成年组为18～5+岁(平均25.75±8.33岁),女性小于男性(P＜0.05);儿童组为4～16岁(平均11.73±2.54岁),未见性别差异(P＞0.05).②诊断率及心率变化:POTS诊断率在年龄组间无差异(P＞0.05),女性比例成年高于儿童;倾斜试验10 min内心率增加量在年龄组间及男女间未见差异(P＞0.05).结论POTS病程及心率增加量不存在年龄和性别差异,成年患者发病年龄女性＜男性,诊断率无年龄差异,但成年女性比例高于儿童,这对临床上诊治POTS具有指导意义.

Objective To study difference between age and gender in postural taehycardia syndrome （PUTS）. Methods 66 patients of POTS were diagnosed from 316 （male 119 and female 197） ones with syncope and dizziness by head- up tilt table test （HUTT）. They were 4 to 70 years old （mean 23.92 ± 16.36 years ）. The patients were divided into adults group （ 〉 18 years old） and children group（ ≤ 18 years old）according to the age. The course of disease, diagnostic rate, changes of heart rate in POTS and their relationship with age and gender were analysed. Results ①The course and onset age in POTS： The course was 1.00 to 11.33（mean 5.22 ± 4.33）years in adults, which was slightly shorter in male than that in female（3.00 ± 4.24 years vs 5.71 ± 4.44 years, P 〉 0.05）. In children group, the course was 0.08 to 4. 00（ mean 0.73 ± 1.13） years and male＇ s was longer than female＇ s （ 1.21 ± 1.46 years vs 0.46 ± 0.81 years, P 〈 0.05）. The adults＇ onset age in POTS was 18 to 49 years old（mean 25.75 ± 8.33 years old） ,and female was younger than male （ P 〈 0.05）. It was 4 to 16 years old （mean 11.73 ± 2.54 years old）in children group without significant difference in gender（ P 〉 0.05）. ②The diagnostic rate and changes of heart rate in POTS： The diagnostic rate in POTS was not different in age but female patients was higher in adults than in children（ P 〉 0.05）. There was no difference in heart rate increment within 10 minutes during HUTT between age groups and gender ones（ P 〉 0.05）. Conclusions There were no differences of age and gender in the course and heart rate increment within 10 minutes during HUTT of POTS. Female patients are more than male ones in adults. There were also no difference of age in the diagnostic rate, but female＇ s was higher in adults than in children. That was of instructive significance to the diagnosis and treatment of POTS in clinic.