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抗雌激素药三苯氧胺制备方法的进展 被引量:1

Progress in Synthesis of antihormones Tamoxifen
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摘要 通过逆向合成分析法和国内外文献归纳成10条合成路线,对每条路线评价其优缺点,并建议方法2.1.2具有工艺路线短、收率高、Z式含量高等特点,值得进一步的研究。参考文献26篇。 Ten types of synthesis methods for antihormones tamoxifen were reviewed through the converse-synthesis-analysis method and their advantages and disadvantages were commented with 26 references . The method 1.1.2 is recommended because it has the advantages of short technical route, high yield, high content of Z type and so on.
作者 徐峰 胡惟孝
出处 《浙江化工》 CAS 2005年第11期19-21,37,共4页 Zhejiang Chemical Industry
关键词 三苯氧胺 他莫昔芬 逆向合成分析法 合成 综述 tamoxifen converse-synthesis-analysis method synthesis review
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参考文献25

  • 1梅和珊,武引文,聂辉.他莫昔芬合成路线图解[J].中国医药工业杂志,2001,32(1):45-47. 被引量:3
  • 2Paul L C and Clare E S. Crossed coupling of functionalised ketones by low valent titanium ( the McMurry reaction ): a new stereoselective synthesis of tamoxifen [J].J.Chem.Soc.Perkin.Trans ( 1 ), 1986:475-477.
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