男性不育不同精液参数患者精浆α-糖苷酶活性测定

Relationship between the main seminal parameters and seminal plasma alpha-glycosidase activity in male infertile patients

目的:测定男性不育不同精液参数患者精浆α糖苷酶活性。方法:对480例不育男性及45例正常对照受试者的精液标本,进行精液常规分析及α糖苷酶活性测定。比较不同精液液化程度、精子密度、活动率和活力患者α糖苷酶活性。结果:①按液化程度分组,不育各组患者精浆α糖苷酶活性与正常对照组差异无统计学意义(P>0.05);②按精子密度分组,梗阻性无精子症组精浆α糖苷酶活性明显低于其他组(P<0.05);③按精子活动率或活力分组,低活动率和低活力组精浆α糖苷酶活性明显低于正常对照组、正常活动率和正常活力组(P<0.05)。结论:精浆α糖苷酶活性可以作为判断男性生育力的参考指标。

Aim： To investigate the relationship between the main seminal parameters and seminal plasma alpha-glycosidase activity in male infertile patients. Methods： The routine semen analysis and the activity of alpha-glycosidase in seminal plasma in 45 normal controls and 480 infertile men were performed. Results： There were no significant differences in seminal plasma alpha-glycosidase activity among liquefaction group, partial liquefaction group, all liquefaction group and normal control group （P 〉 0.05） ; the seminal plasma alpha-glycosidase activity in obstructive aspermia group was significantly lower than those in infertility with normal sperm density group, and normal control group（ P 〈 0.05 ） ; the seminal plasma alpha-glycosidase activity in lower sperm viability or lower motility infertility group was significantly lower than those in normal control group and infertility with normal sperm viability or motility group （ P 〈 0.05）. Conclusion ： The decrease of seminal plasma alpha-glycosidase activity may be used as a parameter for diagnosing the fertile dcapability.