肺癌组织中血管内皮生长因子的表达

Expression of VEGF in lung cancer tissue

目的:观察肺癌组织中血管内皮生长因子(VEGF)的表达。方法:采用免疫组化方法(LSAB法)检测114例肺癌组织(腺癌50例,鳞癌42例,腺鳞癌22例;低分化癌41例,中分化癌48例,高分化癌25例;PTNM分期:Ⅰ+Ⅱ期56例,Ⅲ+Ⅳ例期58例;有淋巴结转移66例,无淋巴结转移48例)、相应的癌旁组织及30例肺良性病变组织中的VEGF的表达水平。结果:①肺癌组织中VEGF阳性细胞率(78.70±17.11)%高于肺癌旁组织(46.76±21.97)%和肺良性病变组织(17.70±15.53)%(P均<0.01),肺癌旁组织高于肺良性病变组织(P<0.05);②VEGF表达水平与肺癌肿块大小、淋巴结转移、PTNM分期、细胞分化程度均有关(P<0.05)。结论:VEGF参与了肺癌的发生、发展、转移,可作为评估肺癌生物学行为的一项指标。

Aim： To study the VEGF expression and its relation to the pathophysiology characteristics in lung cancer tissue. Methods： The expression of VEGF was detected in 114 cases of lung cancer,paracancerous lesion,and 30 cases of benign pulmonary lesion tissue using immunohistochemical staining（LSAB methods）. Results： VEGF expression in lung cancer tissue（ （78.70 ± 17.11 ） % ） was significantly higher than those in paracancerous lesion （ （ 46.76±21.97 ） % ） and benign pulmonary lesion tissue（ （ 17.70±15.53 ） % ） （ P 〈 0.01 ） , the same result was observed between paracancerous tissue and benign pulmonary tissue（P 〈 0.05 ）. VEGF expression was closely correlated with the size of primary cancer, lymph node status, P-TNM stages, grade of cell differentiation of lung cancer（ P 〈0. 05 ）. Conclusion： It is suggested that overexpression of VEGF gene olavs an important role in the oncogenesis, development ,and metastasis of lung cancer and may serve as a tumor marker to evaluate the biological behavior of lung cancer.