1shii H, Takada K. Bleomycin induces E-selectin expression in cultmred umbilical vein endothelial cells by increasing its mRNA levels through activation of NF-kappaB/Rel [ J ]. Toxicol Appl Pharmacol,2002,184 (2) :88 - 97.
2Massey T E, Leeder R G, Rafeiro E, et al. Mechanisms in the pathogenesis of amiodarone-induced pulmonary toxicity[ J]. Can J Physiol Pharmacol,1995,73 (12): 1675-1685.
7Itoh Y,Sendo T,Hirakawa T,et al. Similarity and difference in the acute lung injury induced by a radiagraphic contrast medium and an anticancer agent paclitaxel in rats[ J]. Toxicol Lett,2004,152( 1 ):27 - 34.
9Fanucchi M V, Day K C, Clay C C, et al. Increased vulnerability of neonatal rats and mice to l-nitronaphthalene-induced pulmonary injury[ J]. Toxicol Appl Pharmacol,2004,201 ( 1 ) :53 -65.
10DeGeorge J J, Ahn C H, Andrews P A, et al. Considerations for toxicology studies of respiratory drug products [J]. Regul Toxicol Pharmacol, 1997,25 (2): 189 - 193.
5Ren YC, Wang L, He HB, et al. Pulmonary selectivity and local pharmacokinetics of ambroxol hydroehloride dry powder inhalation in rat.[J]. J Pharm Sei, 2009, 98 (5): 1797-803.
6Owen K. Regulatory toxicology consideration for the development of inhaled pharmaceuticals. [J] Chem Toxicol, 2012 (doi: 10.3109/01480545. 648327). Drug 2011.
7DeGeorge J J,Ahn CH,Andrews PA. Considerations for toxicology studies of respiratory drug products[J].{H}Regulatory Toxicology and Pharmacology,1997,(02):189-193.
8Agu RU,Ugwoke MI,Armand M. The lung as a route for systemic delivery of therapeutic proteins and peptides[J].{H}RESPIRATORY RESEARCH,2001,(04):198-209.
