活血定眩丸对椎动脉型颈椎病兔血液流变学、ET、NO的影响

Effects of Huoxue Dingxuan Pill on blood rheology,ET and NO in experimental rabbits of cervical spondylotic vertebral arteriopathy

目的:探讨活血定眩丸治疗椎动脉型颈椎病的疗效及其与血液流变学、血浆内皮素(ET)、一氧化氮(NO)之间的关系。方法:选健康青紫兰兔32只,随机分为正常组、模型组、颈复康治疗组、活血定眩丸治疗组,每组8只,除正常组外其余3组均经C3-5左侧横突侧面注射消痔灵注射液10 mL,2周后重复1次,观察局部组织形态、全身血液流变学、ET和NO的变化,同时观察活血定眩丸对上述指标的影响并与颈复康作对比。结果:模型组颈部肌肉组织出现水肿、萎缩、变性、坏死及炎症等病变,瘢痕化显著;全身血液流变学(全血低切、中切、高切黏度)异常。模型组与其他3组有显著性差异(P<0.05);颈复康组与活血定眩丸治疗组无显著性差异(P>0.05);ET、NO各组间未见显著性差异(P>0.05)。结论:活血定眩丸能有效改善血液流变学,血液流变学水平的高低可反映椎动脉型颈椎病病变的程度及治疗效果,而ET、NO并非是椎动脉型颈椎病的主要发病机制。

Objective ：To explore the treating effects of Huoxue Dingxuan Pill for cervical spondylotic vertebral arteriopathy（CSA） and the relation to blood rheology, ET and NO. Methods：32 health rabbits were divided into 4 groups randomly, every group had 8 rabbits. Except normal group, the rest were injected Xiaozhiling Injection at the level of C3 to C5 transverse process and injected again after 2 weeks. At the end of experiment, blood rheology, ET and NO were measured and local tissue form were observed. At the same time, observed the effects of Huoxue Dingxuan Pill to the targets and contrasted with Jingfukang. Results： Cervical muscular tissue of model group arised hydrops, atrophy, degeneration, necrosis and inflammation and so on, and sear was prominent. General blood rheology was unusual, there was prominent difference between model group and the other group（ P 〈0.05）. The level of ET and NO were not change（ P 〉0.05）. Conclusion：Huoxue Dingxuan Pill can improve effectively blood rheology. The level of blood rheology can reflect the degree of CSA and treating effect. ET and NO aren＇t main mechanism of CSA.