尖锐湿疣临床病理及HPV免疫组化检测分析

Clinical pathology of 219 condyloma acuminatum cases and HPV immunohistochemistry studies

目的:探讨尖锐湿疣的准确诊断途径。方法:对219例尖锐湿疣的发病情况、临床表现、病理形态学变化和HPV的免疫组化检测进行综合分析。结果:多发生于40岁以下的中青年女性。男性多发生于阴茎,女性多发生于大小阴唇、会阴、处女膜周围等会阴部位。85.4%有不同程度的发病部位及其周围瘙痒或轻度疼痛感。肉眼外观以小疣状型最多见,其次为乳头状型。病理组织学改变可作出诊断者178例,免疫组化HPV检测阳性率为73.9%。结论:尖锐湿疣大部分可过病理学检查或HPV的免疫组化检测确诊,对病理组织学不典型、免疫组化检测阴性的病例还要结合有关病史、临床表现等综合分析方能确诊。

Objective：to explore the excise diagnosis of condyloma acuminatum.Methods：Analyze synthetically Condyloma acuminatum＇ s morbid status, clinical behavior, pathomorpholgy change and HPV＇s immunohistochemical sense of 219 Condyloma acuminatum patients＇ .Results：This diease always happens among woman under 40 age.h happens to the penis in man and labium majus pudend,labium minus pudend, pefineum locum around hymen in woman.85. 4% patients felt pruitus and some pain,most CA were little verruea and papillary by eyes,178 patients were diagnosed by the change of pathotogic histology. 73.9% patients＇ HPV immunohistochemical sense were positive. Conclusion： Most condyloma acuminatum can be diagnosed by pathological or HPV immunohistochemistry. The patient whose pathologic histology is irrepresentative and HPV immunohistochemical sense is negative can be diagnosed by analyzing synthetically his pathologichistology,HPY immunohistochemical sense,hlstory clinical behaviour.