我国人乳头瘤病毒58型感染与宫颈癌的关系

Investigation on relationship between the papiilomavirus type58(HPV58)infection and cervix cancer in China

人乳头瘤病毒中,第58型是很重要的高度致瘤性病毒之一。采用 Southern 印迹技术对我国14省区1216例宫颈癌及癌前病变组织进行人乳头状瘤病毒58型(HPV58)检测。结果:①各类宫颈组织中,宫颈癌组 HPV58型检出率(7.6%)最高;②南方地区宫颈癌组织中 HPV58型检出率(13.2%)高于北方地区(2.8%),表现出明显的地区差异;③与 HPV16型、18型检出率相比较,在宫颈癌组织中 HPV58型检出率低于 HPV16型,但明显高于 HPV18型。HPV58型与 HPV16型在各类宫颈疾患中的检出强度趋势大致相同。表明,HPV58型感染可能与我国特别是南方地区的宫颈癌病因有关。

HPV58 has been shown to be one of the most important high-oncogenic-risk HPV types.1216 DNA samples from cases of various genital lesions from 14.provinces of China were assayed by Southern-blot hybridization to detect HPV58.The results showed:①among various sources of genital lesions the positive rate of HPV58 was the highest in cervix cancer,②the positive rate of HPV58 in cervix cancer in Southern China was higher than that in North- ern China,③the positive rate of HPV58 was lower than that of HPV16,but significantly higher than that of HPV18. The positive rate of HPV58 increased gradually with the malignant extent of the lesions assayed,which is the same as that of HPV16.The results indicated that HPV58 infection was closely related with cervix cancer in Southern China.