新疆哈密地区乙型肝炎病毒表面抗原阳性的肝病患者丁型肝炎病毒感染状况

Hepatitis D virus infection among patients with hepatitis B virus surface antigen positive in the area of Hami,Xinjiang

应用免疫组织化学方法对新疆哈密地区167例乙型肝炎病毒表面抗原(HBsAg)阳性的肝病患者肝组织中丁型肝炎病毒抗原(HDAg)进行了检测,检出率为22.75%(38/167),表明该地区存在较严重 HDV 感染。HDAg 在肝细胞中表达呈浆型、核型、浆核混合型,不同病理类型肝病 HDAg 检出率无明显差别。38例 HDAg 阳性患者中,7例肝脏病理表现为非特异性改变,16例呈慢性迁延性肝炎,10例表现为慢性活动性肝炎,另有5例不能定型。HDV 感染者的病情变化和转归及其与病毒复制的关系有待于进一步随访观察。

Liver biopsy samples from the patients with hepatitis B virus surface antigen(HBsAg)positive in the area of Hami,Xinjiang were detected for hepatitis D virus antigen(HDAg)using immunohistochemistry method.The positive rate was 22.75%(38/167),which indicated HDV infection in this area was very common.HDAg located in the cytoplasm and/or nuclei of liver cells.No obvious difference of the detection rate and deposite of HDAg in liver cells among varoues pathologic types of liver disease was found.Of the 38 HDAg positive cases,7 had only minor changes of liver tissue(NSC),while 16 were in a relatively stable state.The prognosis and progression of the disease in relation with the replication of HBV and HDV needed further study.