静脉溶栓治疗急性脑梗死17例报告

Intravenous thrombolysis for acute cerebral infarction with a report of 17 cases

目的:评价尿激酶对急性脑梗死静脉溶栓治疗的疗效及安全性。方法:17例急性脑梗死患者用尿激酶100-150万U溶于生理盐水150ml中,30分钟内滴完24小时后用肝素静脉滴注3天,并同时口服华法令抗凝治疗一个月。于溶栓治疗前及治疗后的24h、48h、7天、14天对神经功能缺损程度评分。根据神经功能缺损积分值减少比和患者总的生活能力状态病残的程度评定疗效。结果:17例溶栓治疗有效率,于24小时为58.8%,48小时为70.6%,7天为76.5%,14天为88.2%。其中5例发病3小时内接受溶栓治疗者效果明显优于其余12例于3-6小时内接受溶栓治疗者。结论:急性脑梗死患者及早进行溶栓治疗,效果较为明显。

Objective： To evaluate effectiveness and safety of urkkinase （UK） in the treatment of acute cerebral infarctions.Methods：17 Patients with acute cerebral infarctions received UK 1.0-1.5 MU in normal saline （NS） 150ml inteavenously over 30 minutes. Then heparin was infused intravenously 24h after thrombolysis for 3 days,while warfarin administered for 1 month.The neurological function deficit scale（NFDS） was used to evaluate the neurological deficits and the NFDS scores were recorded on the following time points：pretherapy,24h,48h,7d,14d after thrombolysis.To evaluate the efficiecy by the decrease of the ESS scores and the ability of daily life of those patients.Results： The efficient rate for those 17 cases：at 24h was 58.8%, at48h was 70.6%,on 7th day was 76.5%,on 14th day was 88.2%.Of 5 cases received UK within 3h recovered better than the other 12 cases.Conclusion： Earlier UK-treated subjects had better recovery.