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RNA干扰的研究进展

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摘要 随着人类基因组计划中基因测序的完成,生物学的焦点已经转移到研究基因的功能和它们的调解上,为了确定基因的功能,迫切需要建立有效、经济的分析基因功能的技术.近年来对基因阻断技术的研究有很大进展,并显示了良好前景.基因阻断主要在DNA和mRNA两个水平,后者主要包括反义技术、肽核苷酸及RNA干扰(RNA interference,RNAi).RMAi是一项新兴的生物工程技术,即与靶基因序列同源的双链RNA(double-stranded RNA,dsRNA)引发的广泛存在于生物体中的序列特异性基因转录后的沉默过程.
作者 孔雪 杨磊
机构地区 石河子大学新疆地方与民族高发病省部共建教育部重点实验室
出处 《农垦医学》 2005年第4期313-316,共4页 Journal of Nongken Medicine
关键词 RNA干扰 人类基因组计划 基因测序 生物工程技术 功能基因组学 RNAI技术 靶基因序列 序列特异性 基因功能 阻断技术
分类号 R394 [医药卫生—医学遗传学] R382.31 [医药卫生—医学寄生虫学]
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参考文献24

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二级参考文献20

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农垦医学
2005年 第4期

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