急性心肌梗塞存活者的血清铁蛋白水平

Serum Ferritin Level in Subjects Survived from Acute Myocardial Infarction

方法测定56例急性心肌梗塞(MI)存活者(男性44例,女性12例,平均年龄62岁)与年龄、性别配对的正常人的血清铁蛋白.结果 MI 组铁蛋白水平明显高于对照组(312 μg/L 和213μg/L,P<0.001)。铁蛋白升高主要见于男性(330 μg/L 和211 μg/L,P<0.001)。协方差分析控制年龄、性别、体重指数、腰臀比、血压、血脂质、血糖、胰岛素和吸烟等协变量后,MI 全组和男性组的铁蛋白差异仍非常显著(P=0.01和0.03)。多元逐步回归分析发现铁蛋白水平与脂蛋白(a)、ApoA 和腰臀比有关(P<0.05)。结论 MI 者,尤其是男性 MI 者体内铁贮存增加,铁蛋白是 MI 的一个可能的危险因素。

Aim Study the relationship between body stored iron and myocardial infarction.Meth- ods Serum ferritin level was measured in 56 patients survived from acute myocardial infarction(MI),aged 42 to 78 years and 56 presumbly healthy subjects matching for age and sex served as control.Results Serum ferritin levels were higher in MI group than in control(312μg/L vs 214μg/L,P<0.001).Men with MI had higher ferritin concentration than that of men in control(330μg/L vs 211μg/L,P<0.03). Whereas the iron level of women with MI was of no significance.After adjusting factors such as body mass index,waist and hip ratio(WHR),smoking, blood lipids,glucose,insulin and fibrinogen,the dif- ferences of ferritin levels between total,men MI groups and control were still significant(P=0.001 and 0.03,respectively).Multiple stepwise regres- sion analysis showed Lp(a),ApoA and WHR could influence the ferritin level.Conclusion That sub- jects with MI,especially in men have a high stored iron level,as assessed by elevated serum ferritin con- centration and indicate that high stored iron may be a possible risk factor for coronary heart disease.