高血压患者测定尿微量蛋白的临床价值

Examination of Minimal Urinoproteins in Hypertensive Patients

目的探讨高血压患者测定尿微量蛋白意义。方法用ELlSA 法测定原发性高血压患者晨尿微量蛋白 Alb、IgG、IgA、IgM。结果高血压Ⅰ、Ⅱ期尿 Alb 明显高于正常对照组(P<0.01)。高血压Ⅲ期 Alb 高于正常组(P<0.05),但以 IgM 增高为突出,舒张压大于105 mmHg 组尿 Alb 与正常组比较有显著差异(P<0.01),与舒张压<105 mmHg 组比较明显升高(P<0.01)。急性脑梗塞组尿 Alb 高于正常组,陈旧性脑梗塞组 IgG、IgM 明显升高(P<0.05)。结论测定高血压患者尿微量蛋白,可早期发现其亚临床肾病变,对临床观察病情、判断疗效、提高患者长期生存有一定意义。

Aim To investigate the urine micro- protein in hypertensive patients.Methods Urine ALB,IgG,IgA,and IgM in 60 cases of essential hy- pertension were examined.Results Urine Alb in patients of stage Ⅰ,Ⅱ and Ⅲ is higher than that in normatensive group(P<0.01).IgM Alb is signifi- cantly higher in the patients with DBP>105 mmHg compared to normal controls(P<0.01).In patients with acute cerebral infartion,urine Alb is increased, while no change has been found in old cases of cere- bral infarction,however,both IgG and IgM are ele- vated.Conclusion Micro urine protein may be an useful index for evaluation of earlier renal damage..