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不同BMPRIB基因型小尾寒羊发情期ERα和PR表达量的研究 被引量:3

Study on Expression of Era and PR Gene in Different BMPRIB Genotype Small Tail Han Sheep in Oestrum
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摘要 小尾寒羊BMPRIB基因上存在一个与多胎有关的突变位点,根据该突变位点采用PCRSSCP进行基因分型,利用半定量PCR技术研究发情期小尾寒羊BMPRIB基因型(BB,AB和AA)与ERα和PRmRNA表达量的关系结果显示:在发情期BB型右侧卵巢ERαmRNA水平(0.48)高于AA(0.27)和AB(0.24)型,但左侧卵巢则是AA(0.56)型高于AB(0.40)和BB(0.39)型;BB型右侧卵巢PR的mRNA水平(0.82)也高于AA(0.37)和AB型(0.20)而左侧卵巢各基因型基本无差异。这表明小尾寒羊多胎可能与PRmRNA表达量有关。
出处 《中国畜牧杂志》 CAS 北大核心 2005年第11期27-30,共4页 Chinese Journal of Animal Science
基金 国家高技术研究发展计划资助(2002AA241181)
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  • 1Mulsant P, Lecerf F, Fabre S, et al. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes [ J ]. Proc Natl Acad Sci USA, 2001, 98: 5104-5109.
  • 2Iwai M, Yasuda K, Fukuoka M, et al. Luteinizing hormone induces progesterone receptor gene expression in cultured porcine granulosa cells[J]. Endocrinology, 1991, 129:1621-1627.
  • 3Park-Sarge O K, Mayo K E. Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3', 5'-monophosphate in rat granulosa cells [ J ]. Endocrinology,1994, 134: 709-718.
  • 4张英杰,刘月琴,储明星.小尾寒羊高繁殖力和常年发情内分泌机理的研究[J].畜牧兽医学报,2001,32(6):510-516. 被引量:56
  • 5Pamela A H, Theo H, Shirin A, et al. MADR1, a MAD-related protein that functions in BMP2 signaling pathways [ J ].Cell, 1996, 85: 489-500.
  • 6Souza C J H, Macdougall C, Campbell B K, et al. The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic protein receptor type IB ( BMPRIB )gene[J]. J Endocrinol, 2001, 169: R1-R6.
  • 7Wu Liyu, Wu Yalei, Bill Gathings, et al. Smad4 as a transcription corepressor for estrogen receptor [J]. J Biol Chem,2003, 278 (17): 15192-15200.
  • 8Yamamoto T, Aatcioglu F S, Matsuda T. Cross-talk between bone morphogenic proteins and estrogen receptor signaling[J]. Endocrinology, 2002, 143 (7): 2635-2642.
  • 9Thomson A J M, Gazvani M R, Wood S J, et al. Comparison of ovarian response in right and left ovaries in IVF patients[J]. Hum Reprod, 2001, 16 (8): 1694-1697.
  • 10Scaramuzzi R J, Downing J A. The distribution of ovulations from the ovaries of Merino and Border Leicester X Merino ewes and its effect on the survival of their embryos[J]. Anim Reprod Sci, 1997, 47 (4): 327-336.

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