静脉预注联合泵内应用阿扎司琼预防术后自控镇痛恶心呕吐的临床研究

目的观察阿扎司琼静脉预注和泵内联合应用对硬膜外术后镇痛引起的恶心呕吐的效果。方法选择硬膜外麻醉下行妇科手术病人118例,均于术后经硬膜外行自控镇痛,随机分为两组:A组(58例)静脉预注阿扎司琼10mg、B组(60例)静脉预注阿扎司琼10mg,联合泵内阿扎司琼10mg,观察注药后48h恶心呕吐情况。结果A组在术后6h恶心、呕吐与B组比较差异无显著性;术后7～24h,B组呕吐发生率明显低于A组;术后第2个24h,B组的恶心、呕吐发生率均明显低于A组;结论静脉预注和泵内联合应用阿扎司琼可增强防治PONV的效果。

Objective To evaluate the effect of azasetron on prevention nausea and vomiting caused by postoperative epidural analgesia by intravenous infusion associated with epidural pump. Methods 118 patients underwent gynecologic operation were randomly divided into two groups, all of them used by epidural analgesia postoperative, control group treated by intravenous infusion of azasetron（ n = 58 ）, test group treated by intravenous infusion associated with epidural pump of azasetron （ n = 60）. postoperative nausea and vomiting after 48 hours were analyzed. Results There were no difference between control group and test group in postoperative 6 hours（p 〉 0.05）. The incidence of nausea is significantly lower in test group than in control group in postoperative 7 - 24 hours （p 〈 0.05）. Incidence of nausea and vomiting are significance lower in test group than in control group after 24 hours（p 〈 0.05）. Conclusion Azasetron by intravenous infusion associoated with epidural pump could enhance effect on postoperative nausea and vomiting.