摘要
为比较几种天然产物的美白效果及细胞毒性大小,采用小鼠B16黑色素细胞为受试细胞,分别研究了熊果苷及两种不同的海藻多糖对黑色素细胞的细胞毒性、酪氨酸酶活性和黑色素合成的影响。结果表明:熊果苷具有明显的细胞毒性,与之相比,海藻多糖对黑色素细胞活力几乎无影响;3种药物对细胞内酪氨酸酶活性及黑色素合成均有浓度依赖性的抑制作用,且熊果苷的抑制作用高于海藻多糖。
To study the toxicity and lightening effect of several natural active products on cultured B16 melanocytes cells of mouse, arbutin and two kinds of algal polysaccharide were added into B16 melanocytes cells and the cell viability, tyrosinase activity and melanin content were measm~ respectively. The results showed that arbutin has significant cytotoxicity, while algal polysaccharide has little effect on the cell viability. All of them showed a concentration corrective reduction on tyrosinase activity and melanin content, while the inhibition effect of arbutin is better than that of algal polysaccharides.
出处
《日用化学工业》
CAS
CSCD
北大核心
2005年第6期361-363,379,共4页
China Surfactant Detergent & Cosmetics
基金
广东省自然科学基金团队资助项目(粤科基办[2003]11号)
