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乙酰肝素酶在妇科肿瘤中的研究进展 被引量：3

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摘要 肿瘤细胞的浸润和转移是恶性肿瘤的标志性生物学行为,也是肿瘤始终难以攻克的最大障碍。乙酰肝素酶(heparanase,HPA)通过降解细胞外基质(ECM)中的硫酸乙酰肝素多聚糖蛋白和释放其结合的生长因子如碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)和各种酶等加速肿瘤浸润和新生血管形成这两个肿瘤发展的关键环节,从而促进肿瘤的浸润和转移。其基因的成功克隆和分子机制的深入研究为肿瘤治疗提供了新的方向。
作者 崔红梅 王海琳
机构地区 兰州大学第一医院
出处 《国外医学（妇产科学分册）》 2005年第6期371-373,共3页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 乙酰肝素酶 妇科肿瘤 硫酸乙酰肝素多聚糖蛋白 血管生成 转移
分类号 R737.3 [医药卫生—肿瘤]
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参考文献20

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同被引文献28

  • 1刘玉,辛小燕,严瑞兰,刘淑娟,宋晖.乙酰肝素酶基因表达对人卵巢癌细胞系侵袭转移能力的影响[J].陕西医学杂志,2006,35(2):134-137. 被引量：5
  • 2E Baker, J Crawford, G R Sutherland, et al. Human HPA endoglycosidase heparanase. Map position 4q21. 3[J]. Chromosome Res. , 1999,7(4) :319-321.
  • 3Vlodavsky, Friedmann Y, Elkin M, et al. Mammalian heparanase:gene cloning, expression an d function in tumor progression and metastasis[J]. Nat Med, 1999,5 (7) :793-802.
  • 4Gohji K, Katsuoka Y, Okamoto M, et al. Human heparanase:roles in invasion and metastasis of cancer [J]. Hinyokika Kiyo,2000,46(10):757-762.
  • 5Eccles SA. Heparanase: breaking down barriers in tumors[J], Nat Med, 1999,5 (7) : 735-736.
  • 6Vlodavsky, Yael Frienmann, Michael Elkin, et al. Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis [J]. Nature Medicine, 1999,1 (5) : 793-802.
  • 7M Bernfield, M. Gotte, P W Park, et al. Functions of cell surface heparan sulfate proteoglycans[J]. Annu. Rev. Biochem. ,1999,68:729-777.
  • 8L Kjellen, U Lindahl. Proteoglycans: Structures and interactions[J]. Annu Rev Biochem, 1991, 60: 443- 475.
  • 9Gohji K, Katsuoka Y, Okamoto M, et al. Human heparanase: roles in invasion and metastasis of cancer [J]. Hinyokika Kiyo,2000,46(10):757-762.
  • 10Osama n, EI-Assal, Akira Y, et al. The clinico-pathological significance of heparanase and basic fibroblast growth factor expressions jin hepatocellular carcinoma [J]. Clin Can-cer Res,2001,7(5):1 299-1 305.

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国外医学（妇产科学分册）
2005年 第6期

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