克林霉素注射剂临床应用安全性调查与评价

Investigation and Evaluation of Clinical Safety of Clindamycin Injection

目的:安全应用克林霉素注射剂。方法:以自制调查表等形式对2004年3月22日~2004年4月27日我院应用克林霉素注射剂的167例住院患者进行追踪调查和分析。结果:应用克林霉素预防感染98例,治疗感染76例;联合其它抗菌药物预防和治疗感染107(47+60)例;用药剂量0·6g^1·2g,bid,平均用药(17±15)d;不良反应发生率6·6%(11/167),主要表现为恶心、呕吐、腹泻、口唇麻木、发热、霉菌感染等。结论:只有严格掌握用药指征和方法,方可提高用药安全性。

OBJECTIVE： To utilize the clindamycin injection safely. METHODS： 167 cases of hospitalized patients, who underwent ciindamycin injection during the period between March 22, 2004 and April 27, 2004 were followed up and analyzed through the self-made questionnaires. RESULTS： 98 cases were for preventing infections; 76 cases were for treating infections; in 107（47＋ 60） cases clindamycin injection was used in combination with other anti- infective drugs to prevent and treat infections; the average dosage was 0.6g-1.2g, bid, and the average length of time was （17± 15）d; the incidence of ADR was 6,6% （11/ 167）, and the main clinical manifestations were sickness, vomiting, diarrhea, numbness of mouth and lip, fever, and mycoinfection. CONCLUSION： Only by strict control of signs for drug use and ways of administration can the clinical safety be improved.