摘要
目的:评价重组人p53腺病毒注射液(rAd-p53)联合化疗治疗恶性体腔积液的疗效。方法:50例恶性体腔积液患者随机分为治疗组与对照组,治疗组行穿刺引流后腔内注射rAd-p531×1012VP,在rAd-p53注射后48h体腔内再注入顺铂60mg/m2,1次/wk,疗程3wk^4wk;对照组除不给予rAd-p53外,腔内化疗与治疗组相同。结果:治疗组与对照组有效率分别为85·7%、51·7%(P<0·05);治疗组毒副反应主要为自限性发热,12h^24h后自行恢复正常。结论:rAd-p53联合化疗控制恶性体腔积液疗效好、安全。
OBJECTIVE: To evaluate the clinical efficiency of chemotherapy in the treatment of malignant body cavity effusion were randomly divided into 2 groups, The treatment group were recombinant adenovirus p53 injection (rAd- p53) combining METHODS: 50 cases with malignant body cavity effusion given intracavitary administration of rAd-p53 1 × 10^12VP after puncture drainage, 48h later which were given intracavitary administration of 60mg/ m^2 cisplatin once a week for 3-4 weeks, The control group was given the same intracavitary therapy as the treatment group but without tad - p53 therapy, RESULTS: The total effective rates of the treatment group and the control group were 85, 7% and 51, 7% (P〈 0, 05), respectively, The toxic reaction was chiefly manifested as self- limited fever and which disappeared automatically in 12-24h, CONCLUSION: It is safe and effective to use rAd- p53 in the treatment of malignant body cavity effusion,
出处
《中国药房》
CAS
CSCD
北大核心
2005年第23期1809-1810,共2页
China Pharmacy
关键词
重组人P53腺病毒注射液
恶性体腔积液
基因治疗
化疗
Recombinate human p53 adenovirus injection
Malignant body cavity effusion
Gene therapy
Chemotherapy