葛根素-7-磷酸二乙酯的NMR研究

Synthesis and NMR Characterization of Diethyl Puerarin-7-yl Phosphate

葛根素是从常用中药野葛根中分离提取出来的一种具有很强生物活性的异黄酮碳苷类化合物,设计并合成了一种新的化合物葛根素-7-磷酸二乙酯.在常温下,这种新的化合物在NMR谱上有两组相关的信号峰,即在溶液中以两种不同的构象存在.本文利用HSQC和HMBC等多种二维核磁共振技术对这种化合物的NMR谱进行了全归属.

Puerarin, an isoflavone compound, is the bioactive component of traditional Chinese medicine puerarin lobate （wild）. A novel diethyl puerarin-7-yl phosphate was synthesized by the Atherton-Todd reaction with high productive yield. It was found that the compound synthesized has two sets of NMR signals at room temperature, suggesting the existence of two conformational isomers in solution. The ^1H chemical shifts of the compound were assigned using two-dimensional NMR techniques, including ^1H-detected heteronuclear multiple-quantum coherence and ^1H-detected multiple-bond heteronuclear multiple-quantum coherence.