原发性高血压病人血清瘦素水平与胰岛素抵抗的相关性研究

The Relationship Between Serum Leptin Levels and Insulin Resistance in Hypertensive Patients

目的探讨高血压病人血清瘦素水平与胰岛素抵抗的关系。方法分别选择男性女性合并肥胖或非肥胖的高血压病人和正常血压者。测定收缩压(SBP)、舒张压(DBP)、身高、体重、腰围、臀围、血清瘦素水平、空腹血糖和胰岛素水平并计算体重指数(BMI)、腰臀比(WHR)、胰岛素敏感指数(ISI)。分析高血压病人血清瘦素水平与胰岛素敏感指数的关系。结果无论男女血清瘦素水平在同一体质水平(肥胖或非肥胖)高血压组高于正常血压组,同一血压水平(高血压或正常血压)肥胖组高于非肥胖组,ISI则成相反趋势的变化。除男性高血压病肥胖组与非肥胖组ISI差异无显著性,其余上述各组比较差异均有显著性。男性病人血清瘦素水平与ISI存在相关性,女性病人二者未见相关性。结论高血压病人存在高瘦素血症和胰岛素抵抗,男性病人血清瘦素水平与ISI高度相关。

Objective To investigate the relationship between serum leptin levels and insulin resistance in hypertensive patients. Methods Serum glucose, insulin, insulin sensitivity index （ISI） and serum leptin concentrations were determined in 60 men, 50 women with essential hypertension and 50 men, 40 women normotensive.The correlations between leptin and ISI were analyzed. Resuits Serum leptin levels were significantly higher in hypertensive than in normotensive and higher in obesity subjects than in nonobesity ones. ISI of nonobesity was higher than obesity in normotensive group, but both obesity and nonobesity ISI was higher in normotensive group than in hypertensive one. The analysis indicated that serum leptin levels are highly correlated with ISI in male hypertensive patients and nocorrelated in female ones. Conclusions Hypertensive patients have IR and highly serum leptin levels. Serum leptin levels are highly correlated with ISI in male hypertensive patients and nocorrelated in female ones.