补肾健骨汤对膝关节病患者氧自由基代谢的影响

Effect of Bushen JIangu Tang on oxygen free radiCAl metabolism of patients with osteoarthritis of knee joint

对５８例膝关节病患者用补肾健骨汤治疗前后的红细胞超氧化物歧化酶（ＳＯＤ）及血清脂质过氧化物（ＬＰＯ）含量进行了动态检测。结果：患者治疗前ＳＯＤ活性低于正常，ＬＰＯ含量高于正常（Ｐ均＜０．０１）。经治疗病情好转者其氧自由基代谢指标相应改善，显效者恢复正常，无效者仍异常。提示氧自由基可能参入骨关节病的病理过程；补肾健骨汤治疗骨关节病的机理与其改善患者体内氧自由基代谢的紊乱状况有关。

Fifty eight cases of osteoarthritis(OA) of knee joint were treated by oral taken Bushen Jiangu Tang(BSJGT).Before and after treatment the observation of oxygen free radical metabolism have been taken through the activity of superoxide dismutase(SOD) of RBC and the content of lipid peroxide(LPO) of serum.The results showed that before treatment SOD activity decreased significantly and LPO content increased markedly in patients with OA than that in controls(P<0.01).After treatment with BSJGT by oral administration parameter of SOD and LPO had been shown relevent improvement in the remission patients and that in the obvious effective cases returned to normal(P>0.05) and that in ineffective cases remained abnormal(P<0.01).This preiminary study suggested that oxygen free radical might take part in the pathological process of OA and one of therapeutic mechanism of BSJGT is probably due to improving metabolic disorder of the oxygen free radical in patients with OA of knee joint.