摘要
目的探讨儿童肾移植尤其是低年龄儿童肾移植的手术策略、围手术期处理及肾移植对儿童生长发育的影响.方法回顾性分析及比较我院19例16岁以下儿童肾移植的临床资料.结果术后出现肾功能延迟恢复3例,3个月内急性排斥2例,1年人/肾存活率均为100%.CsA剂量4.2～11.4 mg/kg, 平均(7.05±2.03)mg/kg,FK506剂量0.14～0.29 mg/kg, 平均(0.22±0.06 )mg/kg .患儿术前生长发育在正常范围的2例,轻度迟缓7例、中度8例、重度2例.术后1年进入正常生长发育范围的6例,仍为生长发育迟缓的13例(轻度8例,中度迟缓的5例).结论肾移植是治疗儿童终末期肾病的较理想手段,患儿生长发育迟缓均有改善.严格的配型选择、适宜的手术方式和围手术期处理、恰当的免疫抑制策略和良好的依从性是取得良好效果的关键.
Objective To investigate the operative pattern, perioperative management and results of pediatric kidney transplantation. Methods 19 children＇s clinical data undergoing kidney transplantation were retrospectively analyzed. Results Three patients had delayed graft function（DGF） and 2 had acute rejection in 3 months after the operation. One year person and graft survival rates of these 19 cases were both 100%. The dosage of CsA is 7. 05±2. 03 mg/kg（4. 2-11.4 mg/kg. The dosage of FK506 is 0. 22±0.06 mg/kg （0.14-0.29 mg/kg）. The growth of 2 cases was in normal range, 17 cases had growth retardation （7 light cases, 8 medium cases, 2 sever cases） before the operation. There had 6 cases whose growth was in normal range, 13 cases still had growth retardation （8 light cases, 5 medium cases） one year later. Conclusions Kidney transplantation is the ideal therapy of pediatric CRF. Good tissue matching, proper operative pattern and perioperative management are key to transplantation success, as well as appropriate immunosuppression strategy and good compliance.
出处
《中华小儿外科杂志》
CSCD
北大核心
2005年第12期635-637,共3页
Chinese Journal of Pediatric Surgery
关键词
肾移植
生长障碍
免疫抑制
Kidney transplantation
Growth disorders
Immunosuppression
