缬沙坦和氨氯地平对老年原发性高血压病患者左心室和血管内皮舒张功能及胰岛素水平的影响

Influence of valsartan and amlodipine on the left ventricular diastolic function,endothelium function and serum insuline level in aged hyperpietic patients

目的:观察缬沙坦和氨氯地平对老年原发性高血压的降压作用及对左心室舒张功能,血管内皮舒张功能,胰岛素抵抗的改善作用. 方法:选择1～2级老年高血压患者40例,随机分为缬沙坦治疗组和氨氯地平治疗组,分别治疗12周,每周测血压2次,观察两组患者治疗前后血压、心率及胰岛素敏感性的变化,左心室舒张功能以及内皮依赖性血管舒张功能的变化. 结果和结论:缬沙坦组和氨氯地平组均可有效地降低1～2级老年原发性高血压患者的血压,改善左心室舒张功能、胰岛素抵抗及内皮依赖性血管舒张功能.

Objective ： To observe the effect of valsartan and amlodipine on the reduction of blood pressure in aged hyperpietic patients, as well as on the improvement of left ventricular diastolic function, endothelium function and insuline resistence. Methods： We divided 40 cases of aged hypertension patients （ 1 to 2 grade） into Valsartan and Amlodipine groups at random, giving valsartan 80-160 mg or amlodipine 5-10 mg, respectively, for 12 weeks as a treating period. We measured the blood pressure twice a week, observed the differences of blood pressure and heart rate before and after the treatment, as well as the changes of insuline sensitivity, left ventricular diastolic function and endothelium vascular disatolic function. Results and Conclusion： Both valsartan and amlodipine can effectivly reduce the blood pressure of aged hypertension patients （ 1 insuline resistance and endothelium dependent to 2 grade）. They can also improve the diastolic function, vascular diastolic function.