藏药黑蕊虎耳草的化学成分

Chemical Constituents of Tibetan Herbal Medicine Saxifraga melanocentra

从黑蕊虎耳草(Saxifraga melanocentra)地上部分的乙醇提取物中分离得到10个化合物,通过波谱分析并与有关对照品比较,将其结构鉴定为山奈酚(1),槲皮素(2),山奈酚-3-O-β-D-葡萄糖苷(黄芪苷)(3),槲皮素-3-O-β-D-葡萄糖苷(4),山奈酚-3-O-芦丁糖苷(5),芦丁(6),2″-O-没食子酰芦丁(7),岩白菜素(8),没食子酸(9)和没食子酸甲酯(10),除化合物2、6、8和10外,其余6个化合物均为首次从虎耳草属植物中得到。这些成分的鉴定为该植物的药效学研究提供了新的化学依据。

From the aerial parts of Saxifraga melanocentra, ten compounds were isolated and identified with spectral analysis and compared with authentic samples as kaermpferol （1）, quereetin （2）, kaempferol-3- O-β-D-glueoside （ 3 ）, quercetin-3- O-β-D-glucoside （ 4 ）, kaempferol-3-rutinoside （ 5 ）, rutin （6）, 2＂-O-galloylrutin （7）, hergenin （8）, gallic acid （9） and methyl gallate （10）. Six compounds were found from the plant for the first time with the exception of 2, 6, 8 and 10. These results provided new chemical evidences for the bioaetive investigation of this plant.