青春发育期男孩尿液中睾酮及精子的检查

Urinary testosterone levels and sperm emission in urine of adolescent boys

本文对１６４例１０～１４岁中小学生进行两年纵向随访，调查晨尿中出现精子（精尿）的阳性率（６１％），及连续６天精尿的阳性频数（１～４次）。又以放射免疫法测定同期晨尿中睾酮含量，结果其浓度与相同个体同日的血清睾酮浓度呈正相关（ｒ＝０．６，Ｐ＜０．０５）。１６４例的尿睾酮水平随年龄而升高，呈显著性差异。精尿阳性与精尿阴性的标本，尿睾酮亦以前者显著高于后者。连续６日晨尿中阳性精尿频数与其尿睾酮水平比较，则以高频数（３～４次）者大于低频数者（１～２次）。

One hundred sixty four adolescent boys aged 10～14 years old were studied longitudinally for 2 years to investigate the rate of positive spermaturia, its frequency through 6 consecutive days morning voided urine as a batch sampling collected every 6 months. Urinary testosterone (UT) was measured from the first sampling of each batch by radioimmunoassay. Results of UT concentrations or corrected by urine creatinin as UT/Cr show positive correlation with their serum testosterone levels on the same day morning (r=0.6, 0.61, P<0.05). The UT concentrations or UT/Cr ratios increased accordingly upon the age groups with significant difference among them by variance analysis (F=86.4, 9.4, P<0.0001). Values of UT or UT/Cr in positive spermaturia boys were found higher than those in negative ones as UT 36.8 VS 18.4 n mol/L or UT/Cr 0.54 VS 0.25 (t value 9.35, 6.82 & P<0.0001). UT values were also found more higher in the boys with more frequency of positive spermaturia revealed in samples of each batch (F=3.11, P<0.05), but UT/Cr ratio did not show same facts. Determination of spermaturia and UT levels are ideal indicators for estimation of puberty maturation stages in adolescent boys.