新生儿脑部光学参数的无损检测

Non-Invasive Determination of the Optical Properties of Neonatal Brain

生物组织的光学参数与组织中各种生化、生理以及病理过程密切相关。利用频域近红外光谱技术,使用一个140 MHz的射频振荡源对不同波长的半导体激光管进行调制,通过精确测量距离光源一定距离处光子密度波的相位延迟和幅度衰减,并借助于一个光学参数已知的校准模型,实现了对23个新生儿头部组织光学参数的定量测量。并且根据两个波长(788和832 nm)下的吸收系数的测量结果进一步得到了新生儿脑部组织的生理学参数。实验结果表明,这种便携式的频域近红外光谱系统可以有效地获取新生儿头部的光学和生理学参数。

The absorption and reduced scattering parameters of tissue can provide information on a variety of physiologic processes. In the present paper, the local optical properties of 23 infant foreheads were measured with a two-wavelength （788 and 832 nm） portable frequency-domain NIR spectroscopic techinque, based on a standard reference phantom with known optical properties. The single source-detector separation is 40 mm. The cerebral blood volume and tissue oxygen saturation were also derived from the measured absorption coefficients.