摘要
基于归1000密码子使用频次,从垂直和水平两个方向研究了不同进化阶层宿主-病毒密码子使用的若干统计特征及其协同进化规律。结果表明,病毒密码子和氨基酸多样性总体上高于相应宿主;细菌-噬菌体、真菌-真菌病毒、无脊椎动物-无脊椎动物病毒的密码子使用频次匹配较好,细菌-噬菌体、无脊椎动物-无脊椎动物病毒的氨基酸丰度匹配较好;病毒基因AU含量、AU3s含量总体上高于相应宿主;病毒和宿主密码子第一位碱基含量均GA>CU;密码子第二位碱基含量均A>U>C>G;病毒与宿主编码区碱基的相对分子量和相对π电子共振能总体上存在较明显的跟随现象。病毒和宿主基因在密码子使用频次等多个统计特征方面既呈现协同进化趋势,又有较明显的分化。
Based on frecquency of every codon usage in 1000 codons, Several statistics characteristics of codons used by virus and its host which come from different evolution levels and their coevolution have been studied. The results showed： the diversifies of codon and amino acid in virus are higher than those of their hosts, respectively; the codon usage frequencies of bacteriophage, fungal virus and invertebrate virus match well their hosts, respectivly; as for amino acid abundances, the same match also has been observed among bacteriophage, invertebrate vires and their hosts; as a whole, virus prefers base A/U and codons with A/U at the third position compared with its host; the content of G ＋ A at the first position is higher than that of C ＋ U and the order of base content at the second position is A 〉 U 〉 C 〉 G in both virus and its host; the relative molecular weight and π energy of virus are consistent with those of their hosts in the mass. The results above suggest that virus and its host present not only coevolution but also divergence in molecular level.
出处
《生物信息学》
2005年第4期151-154,170,共5页
Chinese Journal of Bioinformatics
基金
国家自然科学青年基金资助项目(30100122)
