基于S1蛋白的禽传染性支气管炎病毒的分子流行病学研究

Molecular epidemiology of the avian infectious bronchitis virus basing on S1 glycoprotein

禽传染性支气管炎病毒是归属于冠状病毒属的没有DNA阶段的正义单链RNA病毒,以极高的死亡率引起禽呼吸泌尿性疾病的广泛流行,每年都给家禽饲养业造成巨大的经济损失。因此开展禽传染性支气管炎病毒的分子流行病学的研究并开发出相关的疫苗时下就显得迫切而且必要。现在,我们基于序列保守且具有强免疫原性的禽传染性支气管炎病毒粒子外壳刺突S1糖蛋白开展了分子流行病学研究,并提出了用于阻断禽传染性支气管炎病毒侵染的疫苗的可行性开发策略。

Avian infectious bronchitis virus, a kind of ssRNA positive- strand virus which belongs to Coronaviridoe without any DNA stage, is one of the most severe pathogenic agent causing acute, highly contagious respiratory and urogenital disease characterized by high mortality rate in affected avian flocks, rosuhing in gigantic economic loss every year. Thereby, it is urgent and necessary for us to research the molecular epidemiology of avian infectious bronchitis virus, and even develop vaccines basing above basic research results. Here we report the molecular evolution and genetic variation of the avian infectious bronchitis virus basing the conserved nueleotide acid sequence of Slgene encoding the spiker glycoprotein with the strong feature of the antigen immunity, locating on the surface of the avian infectious bronchitis virus particle, and provide the feasible strategy to develop the avian vaccine for effectively perturbing the infection of avian infectious bronchitis virus.