摘要
选用小鼠骨髓细胞微核实验及小鼠睾丸染色体畸变实验探讨叶绿酸铜钠对卷烟焦油（ＴＰＭ）诱变性的抑制作用．结果表明．２５～１００ｍｇ／ｋｇ体重的叶绿酸铜钠可不同程度的降低ＴＰＭ诱导的微核率，抑制率为２８．５１％～５４．９７％，５０、１００ｍｇ／ｋｇ体重的叶绿酸铜钠对小鼠睾丸精母细胞染色体畸变的抑制率分别为４０．６３％、５６．２５％．提示：叶绿酸铜钠对卷烟焦油是一种抗诱变物质．
Samples of total particulate matter from mainatream smoke (TPM) were collected with 20/cs automatic smoking machine.The result has been observed the effectinenesss of CHL as inhibitor of mutagencity of TPM through mouse bone marrow PCE MN test and mouse orchis chromosome aberration test. The result show that chlorophyllin exhibited potent activity against the mutagenic activity of TPM,Caused 28.13%～54.97% inhibition in PCE MN test and 40.83%～56.25% in chromosome aberration test repectively. According to the result we can conclude that ahlorophyll used as antimugenicity or anticarcinogen is very hopeful.
