早期重度颅脑外伤患者测定血小板α-颗粒膜蛋白、溶酶体膜糖蛋白的意义

Significance of serum CD62p,CD63 level in patients with severe head injury

目的探讨早期重度颅脑外伤患者血浆血小板表面α-颗粒膜糖蛋白(alpha-granular membraneprotein,CD62p)、溶酶体膜糖蛋白(lysosome intact membrane protein,CD63)的水平与病情严重程度、预后的相关性。方法87例重度颅脑外伤患者在外伤后12 h、1 d、3 d、5 d、7 d测定血浆CD62p、CD63,并根据预后分为生存组和死亡组。设轻度颅脑外伤患者为对照组。结果重度颅脑外伤患者的CD62p水平在伤后1 d、3 d、5 d比伤后12 h时有明显的升高(P<0.05),而CD63水平在伤后1 d、3 d、5 d、7 d时与伤后12h时比较,差异有显著性(P<0.05)。在外伤后的12 h、1 d,生存组与死亡组患者的CD62p、CD63水平与对照组比较,差异有显著性(P<0.05)。而且,死亡组的CD62p、CD63水平比生存组明显升高(P<0.05)。结论血小板活化程度与重度颅脑外伤患者的病情严重程度及其预后相关。

Objective To determine the changes of patients with severe head injury and the relationship among the serum level of alpha-granular membrane protein （CD62p）, lysosome intact membrane protein （CD63） , the severity of injury and prognosis. Methods The serum level of CD62p, CD63 was measured in 87 patients with severe head injury on hour 12, day 1, 3, 5, 7 after injured. Eighty-seven patients were divided into two groups： the survive group and the death group. The levels of CD62p, CD63 between two groups were compared. Results The serum levels of CD62p in patients with severe head injury on 1, 3, 5 days after injury were higher than those on 12 hours （ P 〈 0. 05 ） , The serum levels of CD63 on 1, 3, 5, 7 days after injury were higher than those on 12 hours （ P 〈 0. 05） . The serum levels of CD62p , CD63 in the survive group and death group on 12h, ldays after injury were higher than those in the control group （ P 〈 0. 05） , and the serum levels of CD62p , CD63 in the survive group were higher than those in the death group .Conelusion It was helpful in judging the severity of head in jury and prognosis to determine the serum levels of CD62p, CD63 in patients with severe head injury.