安痛定注射液致196例不良反应文献分析

A Literature Analysis of 196 Cases of Adverse Drug Reactions Induced by Antongding Injection

目的探讨安痛定注射液所致不良反应(ADR)的一般规律及其特点,为临床合理用药提供参考。方法对国内医药期刊报道的196例安痛定注射液致ADR病例进行统计分析。结果安痛定注射液所致ADR临床表现复杂多样,累及皮肤及其附件、呼吸、神经、心血管、消化、血液、免疫、肌肉、骨骼、泌尿等多个器官系统,严重者可导致死亡。结论安痛定注射液所致ADR以中、重度为主,用药潜在危害大,应引起临床高度警惕和关注。

Objective To study the general pattern and characteristics of 196 cases of adverse drug reactions induced by antongding injection, so as to provide reference for drug application on clinic safely. Methods A metrological analysis was conducted on 196 cases of adverse drug reactions drug reactions induced by antongding injection reported in domestic medical journals. Results The adverse was involved in the skin and its appendages, respiratory system, nervous system, cardiovascular system, gastrointestinal trace, blood system, immune system, muscle and skeleton systems, urinary system, etc, seriously leading to death. Conclusion The adverse drug reactions induced by antongding injection were mainly moderate and sever reactions, also there is latent harm when it is used, so it should cause highly alert and attention in clinic.