VEGF nm23及树突状细胞表达与乳腺癌预后的相关性研究

Correlation between Expression of Vascular Endothelial Growth Factor、nm23、Dendritic Cell and Prognosis of Breast Cancer

目的探讨血管内皮生长因子(VEGF)、nm23和树突状细胞(DC)在乳腺癌组织中的表达及临床意义。方法应用免疫组化方法,检测60例乳腺癌组织中VEGF、nm23和DC的表达情况,并分析其临床意义。结果VEGF表达依乳腺癌临床分期Ⅰ、Ⅱ、Ⅲ期的顺序而明显上升(P<0.05),同时与乳腺癌有无淋巴结转移密切相关(P<0.05)。VEGF阴性表达组5、10年生存率明显高于阳性表达组(P<0.05)。VEGF阴性表达组nm23和DC表达明显高于阳性表达组(P<0.05)。结论VEGF可作为估计乳腺癌预后、指导制定合理治疗方案的指标。nm23、DC可与VEGF互补,作为判断乳腺癌恶性程度、转移及预后的参与指标。

Objective To explore the expression of vascular endothelial growth factor （VEGF）、nm23 and CD83 positive dendritic cell（CD83^＋ CD） and their clinical significance in human breast cancer. Methods The expressions of VEGF、nm23 and CD83^＋ CD in 60 samples of breast cancer were detected by the immunohistochemical staining, and the results were related to clinical data. Results The expression of VEGF ascended significantly according to the following order of breast cancer of clinical stage Ⅰ, Ⅱ, Ⅲ（P 〈 0.05）. Meantime, the expression of VEGF was prominently determined by positive or negative metastatic node（P 〈 0.05）. The 5-year, 10-year survival rate was significantly higher in patients with negative VEGF expression than those with positive expression（P 〈 0.05） o The nm23 and CD83^＋ DC expressions of the VEGF negative group were significantly higher than those of positive group（P 〈 0.05）. Conclusion VEGF might he a valuable marker in predicting prognosis、guiding the plan of rational therapeutic scheme in human breast cancer. The expressions of nm23 and CD83^＋ DC have reciprocity in judging the malignant degree、metastatic probability and prognosis.