新疆地区汉族220例非酒精性脂肪肝的临床特点和相关危险因素分析

Clinical features and risk factors of nonalcoholic fatty liver disease in Xinjiang area

目的探讨新疆地区汉族人非酒精性脂肪肝(NAFLD)的临床特点和相关危险因素。方法运用回顾性分析结合多元Logistic回归分析,探讨2004-02～2004-07新疆维吾尔自治区中医院门诊体检220例新疆地区汉族NAFLD患者的相关危险因素和临床特点并与220例正常对照组比较。结果NAFLD组血清ALT和AST异常率均高于对照组,其中又以ALT异常率的增高更加明显。与对照组相比,NAFLD易伴发肥胖、Ⅱ型糖尿病、心脑血管疾病、高脂血症等疾病。体重指数(BMI)、舒张压(DBP)、高脂饮食、甘油三酯(TG)和载脂蛋白B(ApoB)与NAFLD的发生呈负相关关系,高密度脂蛋白(HDL)与NAFLD的发生呈正相关关系。结论BMI、DBP、高脂饮食、TG和ApoB为NAFLD的独立危险因素,HDL为其保护因素。定期体检、控制血脂水平、改善原有的不良饮食结构、加强锻炼、控制体重为预防NAFLD及其伴发疾病的重要措施。

Objective To investigate the clinical features and related risk factors of nonalcoholic fatty liver disease （NAFLD） in Xinjiang area for early diagnosis and prevention. Methods Retrospective case - control study was done to explore the clinical features and related risk factors of NAFLD with Logistic regression analysis. Results Levels of serum ALT increased significantly in the patients with NAFLD and were often more than 2 - fold of the normal limit ; serum AST was only increased mildly. Obesity, type 2 diabetes mellitus, heart and brain blood vessel disease and hyperlipidemia were syndromes of NAFLD. BMI, DBP. high lipid food. serum TG, serum ApoB were negatively correlated with the occurrence of NAFLD, while serum HDL was positively correlated with the occurance of NAFLD. Conclusion BMI,DBP,high lipid food,serum TG and serum ApoB may be independent risk factors of NAFLD. To prevent NAFLD and its syndromes, periodical physical examination, changing bad life styles and controlling obesity are most important.