周期蛋白G2在口腔鳞癌中的表达和意义

Expression and significance of cyclin G2 in oral squamous cell carcinoma

目的:探讨细胞周期蛋白G2(cyc lin G2)表达在口腔鳞癌发生和发展中的意义。方法:应用免疫组化S-P法检测39例口腔鳞癌组织和20例正常口腔黏膜组织中cyc lin G2的表达,通过显微图像分析系统分析其阳性率和平均积分光密度值的改变。结果:在正常口腔黏膜组织、高、中和低分化鳞癌组织中cyc lin G2的表达阳性率逐渐降低,分别为95%(19/20)、84.6%(11/13)、80%(12/15)和36.4%(4/11),差异显著(P<0.05);平均积分光密度值分别为1321.36±25.41、927.15±10.37、854.72±12.86和327.11±13.57,差异显著(P<0.05)。结论:cy-c lin G2在口腔鳞癌的发生、发展中起一定作用,是提示肿瘤恶性度的生物学指标之一。

Objective： To explore the role of cyclin G2 in the occurrence and development of oral squamous cell carcinoma （OSCC） by determining the expression and distribution of eyelin G2, Methods： The expression of cyclin G2 was determined by immunohistochemical S-P method in 39 OSCC tissues of and 20 normal oral mueosas. The positive expression rate and average optical density value of cyclin G2 were analyzed by using micro-image analysis system. Results： The positive expression rates of eyelin G2 in normal oral mueosa, highly differentiated OSCC, moderately differentiated OS- CC, and poorly differentiated OSCC were 95.0%, 84.6%, 80.0%, and 36.4%, respectively, and the difference was statistically significant （ P 〈 0. 05 ）. The average optical density values of cyclin G2 in normal oral mueosa, highly differentiated OSCC, moderately differentiated OSCC, and poorly differentiated OSCC were 1 321.36±25.41,927.15 ± 10.37, 854.72 ±12.86, and 327.11 ± 13.57, respectively, and the difference was statistically significant （ P 〈 0. 05）. Conclusion： The expression of cyclin G2 ＂is associated with the degree of differentiation of OSCC. It may serve as ＇a biological marker in evaluating the malignancy of tumor.