摘要
目的:探讨促红细胞生成素(Erythropoietin,Epo)对肾缺血再灌注损伤的保护作用。方法:观察Epo对肾缺血再灌注损伤大鼠血丙二醛(MDA)、肌酐(Cr)、尿素氮(BUN)和肾组织匀浆超氧化物歧化酶(SOD)、白介素-6(IL-6)变化。结果:Epo治疗组血浆MDA、Cr、BUN水平较缺血再灌注组显著下降(P<0.05);肾组织匀浆SOD显著升高、IL-6显著降低(P<0.05)。结论:Epo可提高SOD,降低IL-6对肾缺血再灌注损伤具有保护作用。
Objective： To study the protective effects of erythropoietin（EPO） on renal ischernia/reperfusion（I/R） injury. Methods： The model of renal I/R injury was treated with EPO and then the levels of plasma malondialdehyde（MDA）, ereatine（Cr）, blood urea nitrogen（BUN） and tissue superoxide dismutase（SOD）, interleukin- 6（IL - 6） were determined in rats. Results： The levels of MDA, Cr, BUN and tissue IL - 6 were significantly lower in EPO group than those in I/R group（P〈0. 05）, but the level of SOD was higher in EPO group than in I/R group（P〈0. 05）. Conclusion： EPO has protective effects on renal I/R injury in rats, because it can increase SOD and decrease IL - 6.
出处
《西南国防医药》
CAS
2005年第6期589-591,共3页
Medical Journal of National Defending Forces in Southwest China
