多巴胺转运体SPECT显像鉴别老年ET和早期PD

Differentiating the early Parkinson's diseases from essential tremor by using dopamine transporter SPECT imaging

目的证实99m锝-2β-[N,N’双(2巯乙基)乙撑二胺基]甲基-3β(4氯苯基)托烷(99mTc-TRODAT-1)单光子发射型计算机断层摄影术(SPECT)多巴胺转运蛋白(DAT)显像在老年人原发性震颤(ET)及早期帕金森病(PD)的鉴别诊断价值。方法对12例ET,15例早期PD,15例年龄、性别相匹配的正常人进行99mTc-TRODAT-1SPECTDAT显像。计算纹状体(ST)/小脑(CB)比值来反映纹状体内DAT特异性结合TRODAT-1的量。结果ET患者ST与CBDAT的特异性放射性摄取比值(ST/CB)双侧对称,双侧均数与正常组比较无显著性差异(P>0·05)。PD患者ST/CB双侧不对称,双侧均数与正常组比较有显著差异(P<0·01)。结论99mTc-TRODAT-1SPECTDAT显像可以鉴别ET和PD。

Objective To illustrate the value of ^99mTc-TRODAT-I SPECT dopamine transporter（DAT） imaging for differentiating early Parkinson＇s disease （PD） from essential tremor （ET）, Methods Twelve patients with ET, 15 patients with early PD and 15 age,sex matched healthy subjects were studied by ^99mTc-TRODAT-1 SPECT DAT imaging. Striatum specific uptake of ^99mTc-TRODAT-1 was calculated according to the ratio of stratum（ST） and cerebellum（CB）. Resuits The difference of the means of the bilateral ST/CB ratios of the patients with ET compared with those of the agematched control subjects was not significant. In the patients with early PD, the means of the bilateral ST/CB ratios significantly lower than those of age-matched control. Conclusions ^99mTc-TRODAT-1 SPECT DAT imaging can be used in the differential diagnosis of early Parkinson＇s diseases and essential tremor.