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侵袭性牙周炎牙龈组织中TIMP1基因表达多态性研究 被引量：2

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摘要 目的:探讨TIMP1基因表达多态性与汉族人群侵袭性牙周炎(AP)易感性的关系。方法:收集汉族重度AP女性患者36例及35名无牙周炎女性对照者的牙龈组织,采用标准酚-氯仿抽提法和蛋白酶K消化法提取DNA。用甲基化敏感的限制性内切酶PCR法测定TIMP1基因的甲基化修饰情况,分析对照组与患者组基因表达的差异。结果:重度女性AP患者组中两条X染色体上TIMP1基因都处于去甲基化状态的比例高于对照组,差异有统计学意义。结论:TIMP1基因表达多态性可能与汉族人群AP的易感性有关。
作者 赵红宇 张旭 李得加 肖燕 石爱梅 赵华
机构地区 广东省口腔医院番禺分院 郑州大学生物化学教研室 郑州大学第一附属医院口腔科 郑州大学
出处 《中国卫生检验杂志》 CAS 2005年第12期1502-1503,共2页 Chinese Journal of Health Laboratory Technology
基金 河南省自然科学基金资助项目(411045600)
关键词 牙周炎 TIMP1 疾病易感性 基因表达多态性
分类号 R781.42 [医药卫生—口腔医学]
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参考文献7

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共引文献11

同被引文献25

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引证文献2

二级引证文献4

中国卫生检验杂志
2005年 第12期

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