同胞效应与儿童哮喘的关系探讨

Sibling effect and childhood asthma.

[目的]分析多同胞是否对儿童哮喘有保护作用.[方法]以2000～2002年德国Wilhelmshaven镇和Delmenhorst镇小学入学儿童为研究对象,共4039人.采用的问卷是国际儿童哮喘与过敏性疾病研究第一阶段问卷的核心问题.同胞数与儿童哮喘关系分别在单变量Logistic回归模型中和多元Logistic回归模型中进行验证.[结果]总的儿童哮喘患病率为12.03%;随着同胞数增加,儿童哮喘患病率下降(P＜0.05).同时,在多元Lo-gistic回归模型中加入家族史和室内暴露因素后,对同胞效应影响小.[结论]儿童哮喘患病率受同胞效应影响,家族史和室内暴露因素对同胞效应无显著影响.

[Objective] Effects of ly history and other indoor exposures sibling size on childhood asthma will be tested, by the way, according to fami ly history and other indoor exposures.[Methods] From 2000-2002, Core questions from ISAAC phase Ⅰ are adopted by us to collect the data among school beginners in 2 small towns in northern Germany. Asthma is defined as doctor ever diagnosed asthma or spastic/obstructive bronchitis from parents＇ reports. Prevalence of childhood asthma and prevalence of related exposures including family history and indoor exposures （sibling size, passive smoking, dampness and mould spots in houses, and pet ownership） are obtained at the same time. When family with only one child is defined as the reference group, odds ratios between sibling size and childhood asthma are calculated in univariate and multivariate logistic regression models respectively. [Results] With increase of sibling size, prevalence of childhood asthma decreases; odds ratios have obviously negative dose responsive relationship between sibling size and childhood asthma both in univariate logistic regression models and in multivariate logistic regression models. [Concluposures] Large sibling size has protective effect on childhood asthma. Family histories of allergic diseases and indoor exhave little influence on sibling effect.